Selenoprotein S anticorps (Middle Region)

N° du produit ABIN2783218

Cet anticorps anti-Selenoprotein S est un anticorps Lapin Polyclonal détectant Selenoprotein S dans WB. Adapté pour Humain, Rat, Souris, Chien, Boeuf (Vache), Chévre, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae et Poisson zèbre (Danio rerio). Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour Selenoprotein S anticorps (Middle Region) (ABIN2783218)

Antigène: Selenoprotein S (SELS)

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Chévre, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Selenoprotein S est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Selenoprotein S anticorps

Épitope: Middle Region

Séquence: PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS

Homologie: Cow: 93%, Dog: 86%, Goat: 75%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Yeast: 90%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SELS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SELS

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 189 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Selenoprotein S (ABIN2783218)

Du, Liu, Huang: "Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells." dans: Biochimica et biophysica acta, Vol. 1800, Issue 5, pp. 511-7, (2010) (PubMed).

Moses, Johnson, Tømmerdal, Forsmo, Curran, Abraham, Charlesworth, Brennecke, Blangero, Austgulen: "Genetic association of preeclampsia to the inflammatory response gene SEPS1." dans: American journal of obstetrics and gynecology, Vol. 198, Issue 3, pp. 336.e1-5, (2008) (PubMed).

Zeng, Du, Zhou, Huang: "Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells." dans: Archives of biochemistry and biophysics, Vol. 478, Issue 1, pp. 1-6, (2008) (PubMed).

Détails sur Selenoprotein S

Antigène: Selenoprotein S (SELS)

Autre désignation: SELS

Sujet: SELS is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: AD-015, ADO15, MGC104346, MGC2553, SBBI8, SEPS1, VIMP, SELS
Protein Interaction Partner: UBC, SRPK2, PTGS2, CAV1, DERL2, APOB, DERL1, VCP, KPNB1, AMFR, SYVN1, HERPUD1, SAA1, SVIP, NPLOC4, UFD1L, HSPA4,
Protein Size: 189

Poids moléculaire: 21 kDa

ID gène: 55829

NCBI Accession: NM_018445, NP_060915

UniProt: Q9BQE4

Pathways: Cellular Response to Molecule of Bacterial Origin, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome