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Selenoprotein S anticorps (Middle Region)

SELS Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Chévre, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783218
  • Antigène Voir toutes Selenoprotein S (SELS) Anticorps
    Selenoprotein S (SELS)
    Épitope
    • 7
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    Humain, Rat, Souris, Chien, Boeuf (Vache), Chévre, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)
    Hôte
    • 15
    • 5
    Lapin
    Clonalité
    • 18
    • 3
    Polyclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Selenoprotein S est non-conjugé
    Application
    • 12
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS
    Homologie
    Cow: 93%, Dog: 86%, Goat: 75%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Yeast: 90%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against SELS. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human SELS
    Top Product
    Discover our top product SELS Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 189 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Du, Liu, Huang: "Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells." dans: Biochimica et biophysica acta, Vol. 1800, Issue 5, pp. 511-7, (2010) (PubMed).

    Moses, Johnson, Tømmerdal, Forsmo, Curran, Abraham, Charlesworth, Brennecke, Blangero, Austgulen: "Genetic association of preeclampsia to the inflammatory response gene SEPS1." dans: American journal of obstetrics and gynecology, Vol. 198, Issue 3, pp. 336.e1-5, (2008) (PubMed).

    Zeng, Du, Zhou, Huang: "Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells." dans: Archives of biochemistry and biophysics, Vol. 478, Issue 1, pp. 1-6, (2008) (PubMed).

  • Antigène
    Selenoprotein S (SELS)
    Autre désignation
    SELS (SELS Produits)
    Synonymes
    anticorps ADO15, anticorps SBBI8, anticorps SELS, anticorps SEPS1, anticorps 1500011E07Rik, anticorps C78786, anticorps H-4, anticorps H-47, anticorps H4, anticorps H47, anticorps Sels, anticorps sg2, anticorps selenoprotein S, anticorps SELENOS, anticorps Selenos
    Sujet
    SELS is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
    Alias Symbols: AD-015, ADO15, MGC104346, MGC2553, SBBI8, SEPS1, VIMP, SELS
    Protein Interaction Partner: UBC, SRPK2, PTGS2, CAV1, DERL2, APOB, DERL1, VCP, KPNB1, AMFR, SYVN1, HERPUD1, SAA1, SVIP, NPLOC4, UFD1L, HSPA4,
    Protein Size: 189
    Poids moléculaire
    21 kDa
    ID gène
    55829
    NCBI Accession
    NM_018445, NP_060915
    UniProt
    Q9BQE4
    Pathways
    Cellular Response to Molecule of Bacterial Origin, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome
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