HADHB anticorps (C-Term)

N° du produit ABIN2783232

Détail du produit anti-HADHB anticorps

Antigène: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Porc, Poisson zèbre (Danio rerio), Lapin, Boeuf (Vache), Chien, Saccharomyces cerevisiae, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HADHB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LLLGPTYATP KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 83%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against HADHB. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human HADHB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 474 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HADHB (ABIN2783232)

Chen, Young, Chatham, Crossman, DellItalia, Shalev: "TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling." dans: American journal of physiology. Heart and circulatory physiology, Vol. 311, Issue 1, pp. H64-75, (2016) (PubMed).

Gerin, Clerbaux, Haumont, Lanthier, Das, Burant, Leclercq, MacDougald, Bommer: "Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation." dans: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33652-61, (2010) (PubMed).

Détails sur HADHB

Antigène: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Autre désignation: HADHB (HADHB Produits)

Synonymes: anticorps ECHB, anticorps MTPB, anticorps TP-BETA, anticorps thiolase, anticorps fb14g10, anticorps wu:fb14g10, anticorps zgc:56274, anticorps 4930479F15Rik, anticorps Mtpb, anticorps Hadhb, anticorps hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, anticorps hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta S homeolog, anticorps hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit, anticorps hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit, anticorps HADHB, anticorps hadhb.S, anticorps Hadhb, anticorps hadhb

Sujet: HADHB is the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in HADHB gene result in trifunctional protein deficiency. The protein can also bind RNA and decreases the stability of some mRNAs.This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found, however, their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC87480, MSTP029, TP-BETA, ECHB, MTPB
Protein Interaction Partner: HUWE1, TP53, TUBG1, SUMO2, SUMO3, UBC, PARK2, PPP6R1, ADRB2, CSNK2A2, PAN2, ATF2, vpu, TIMM8B, COX17, IQCB1, SUOX, CHCHD4, TUBB1, RPS8, OPA1, HSP90AB1, HADHA, DES, GRK5, FBXO6, CDK2, LEO1, RTF1, TK1, SMN1, PSMA3, GRB7, RCC1, CDKN1A, ANXA7, Edc4, MYC, SQST
Protein Size: 474

Poids moléculaire: 47 kDa

ID gène: 3032

NCBI Accession: NM_000183, NP_000174

UniProt: P55084

Pathways: Monocarboxylic Acid Catabolic Process