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MEK2 anticorps (N-Term)

MAP2K2 Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783572
  • Antigène Voir toutes MEK2 (MAP2K2) Anticorps
    MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
    Épitope
    • 19
    • 16
    • 12
    • 11
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    N-Term
    Reactivité
    • 135
    • 81
    • 46
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache)
    Hôte
    • 109
    • 25
    • 1
    • 1
    Lapin
    Clonalité
    • 109
    • 27
    Polyclonal
    Conjugué
    • 72
    • 11
    • 11
    • 10
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MEK2 est non-conjugé
    Application
    • 110
    • 61
    • 35
    • 23
    • 21
    • 21
    • 19
    • 15
    • 14
    • 10
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    LARRKPVLPA LTINPTIAEG PSPTSEGASE ANLVDLQKKL EELELDEQQK
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MAP2K2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP2K2
    Top Product
    Discover our top product MAP2K2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 400 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
    Autre désignation
    MAP2K2 (MAP2K2 Produits)
    Synonymes
    anticorps CFC4, anticorps MAPKK2, anticorps MEK2, anticorps MKK2, anticorps PRKMK2, anticorps AA589381, anticorps MK2, anticorps Prkmk2, anticorps ATMKK2, anticorps F27B13.50, anticorps F27B13_50, anticorps MAP KINASE KINASE 1, anticorps MAP kinase kinase 2, anticorps MK1, anticorps map2k2, anticorps wu:fa56c06, anticorps zgc:123171, anticorps zgc:172250, anticorps mitogen-activated protein kinase kinase 2, anticorps mitogen activated protein kinase kinase 2, anticorps MAP kinase kinase 2, anticorps mitogen-activated protein kinase kinase 2a, anticorps mitogen-activated protein kinase kinase 2b, anticorps MAP2K2, anticorps Map2k2, anticorps MKK2, anticorps map2k2a, anticorps map2k2b
    Sujet
    MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MAPKK2, MEK2, MKK2, PRKMK2
    Protein Interaction Partner: CCNDBP1, RAF1, SUMO2, UBC, EGFR, IQGAP1, NFE2L2, YWHAB, MAPK1, PEX14, BRAF, ARAF, FAM65B, ZNF207, LIG4, MAPK8, WDR83, Ksr1, COPS5, MAP2K1, MEPCE, GRIN1, CNKSR1, LAMTOR3, GRIN2D, RGS12, CASP9, MAPK3, MAP2K2, DUSP3, Flna,
    Protein Size: 400
    Poids moléculaire
    44 kDa
    ID gène
    5605
    NCBI Accession
    NM_030662, NP_109587
    UniProt
    P36507
    Pathways
    Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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