Retinoblastoma Binding Protein 8 anticorps (C-Term)

N° du produit ABIN2784374

L’anticorps anti-Retinoblastoma Binding Protein 8 Polyclonal Lapin est utilisé pour la détection de Retinoblastoma Binding Protein 8 dans des échantillons de Humain, Porc, Boeuf (Vache), Chien, Lapin, Cobaye et Cheval. Il a été validé pour WB.

Aperçu rapide pour Retinoblastoma Binding Protein 8 anticorps (C-Term) (ABIN2784374)

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivité: Humain, Porc, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps

Épitope: C-Term

Fonction: RBBP8 Antibody - C-terminal region

Séquence: ETVDMDCTLV SETVLLKMKK QEQKGEKSSN EERKMNDSLE DMFDRTTHEE

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 83%, Horse: 79%, Human: 100%, Pig: 100%, Rabbit: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50887-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: RBBP8

Sujet:

Background Information: RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Gene Name: Retinoblastoma binding protein 8

Alternative Symbols: RIM, COM1, CTIP, JWDS, SAE2, SCKL2

Protein Name: DNA endonuclease RBBP8 Ensembl ENSP00000382630

Poids moléculaire: 98kDa

ID gène: 5932

NCBI Accession: NP_976037

UniProt: A6NKN2

Pathways: Cycle Cellulaire, Réparation de l'ADN