CYP27A1 anticorps (Middle Region)

N° du produit ABIN2784620

Détail du produit anti-CYP27A1 anticorps

Antigène: CYP27A1 (Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP27A1 est non-conjugé

Application: Western Blotting (WB)

Séquence: SRDPTAFSEP ESFQPHRWLR NSQPATPRIQ HPFGSVPFGY GVRACLGRRI

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CYP27A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CYP27A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 531 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CYP27A1 (ABIN2784620)

Szlago, Gallus, Schenone, Patiño, Sfaelo, Rufa, Da Pozzo, Cardaioli, Dotti, Federico: "The first cerebrotendinous xanthomatosis family from Argentina: a new mutation in CYP27A1 gene." dans: Neurology, Vol. 70, Issue 5, pp. 402-4, (2008) (PubMed).

Détails sur CYP27A1

Antigène: CYP27A1 (Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1))

Autre désignation: CYP27A1 (CYP27A1 Produits)

Synonymes: anticorps CP27, anticorps CTX, anticorps CYP27, anticorps Cyp27, anticorps P450C27, anticorps 1300013A03Rik, anticorps cytochrome P450 family 27 subfamily A member 1, anticorps cytochrome P450, family 27, subfamily a, polypeptide 1, anticorps cytochrome P450, family 27, subfamily A, polypeptide 1, anticorps sterol 26-hydroxylase, mitochondrial, anticorps CYP27A1, anticorps Cyp27a1, anticorps cyp27a1

Sujet: CYP27A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CP27, CTX, CYP27
Protein Interaction Partner: PRDX4,
Protein Size: 531

Poids moléculaire: 57 kDa

ID gène: 1593

NCBI Accession: NM_000784, NP_000775

UniProt: Q02318