EGLN3 anticorps (C-Term)

N° du produit ABIN2784911

Détail du produit anti-EGLN3 anticorps

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN3 est non-conjugé

Application: Western Blotting (WB)

Séquence: FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 77%, Zebrafish: 75%

Attributs du produit: This is a rabbit polyclonal antibody against EGLN3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human EGLN3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 239 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EGLN3

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Autre désignation: EGLN3 (EGLN3 Produits)

Synonymes: anticorps zgc:77019, anticorps wu:fj78a08, anticorps EGLN3, anticorps phd3, anticorps PHD-3, anticorps PHD3, anticorps SM-20, anticorps 2610021G09Rik, anticorps AI505553, anticorps AI648162, anticorps Hif-p4h-3, anticorps Phd3, anticorps HIFP4H3, anticorps HIFPH3, anticorps egl-9 family hypoxia-inducible factor 3, anticorps egl-9 family hypoxia inducible factor 3, anticorps egl-9 family hypoxia-inducible factor 3 L homeolog, anticorps egln3, anticorps EGLN3, anticorps egln3.L, anticorps Egln3

Sujet: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
Alias Symbols: FLJ21620, HIFPH3, MGC125998, MGC125999, PHD3
Protein Interaction Partner: FOXJ2, SERTAD1, NCAPH2, EFHC2, ABI2, SIAH2, REL, HIF1A, TTC23L, SQSTM1, HEXIM1, IKBKG, IKBKB, CHUK, MAPK7, MAPK6, MAPK1, PKM, EPAS1, UBD, MAGEA11, UBC, ATF4, WTIP, AJUBA, LIMD1, SPRY2, ADRB2, PRPF19, Myog, EGLN3, EGLN2, EGLN1, OS9, HIF3A, WDR83,
Protein Size: 239

Poids moléculaire: 27 kDa

ID gène: 112399

NCBI Accession: NM_022073, NP_071356

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity