PSME2 anticorps (Middle Region)

N° du produit ABIN2786730

Détail du produit anti-PSME2 anticorps

Antigène: PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME2 est non-conjugé

Application: Western Blotting (WB)

Séquence: QEKVLERVNA VKTKVEAFQT TISKYFSERG DAVAKASKET HVMDYRALVH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against PSME2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PSME2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 239 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PSME2

Antigène: PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))

Autre désignation: PSME2 (PSME2 Produits)

Synonymes: anticorps unp309, anticorps PA28B, anticorps PA28beta, anticorps REGbeta, anticorps AA589371, anticorps AI788882, anticorps PA28b, anticorps proteasome activator subunit 2, anticorps proteasome (prosome, macropain) activator subunit 2 (PA28 beta), anticorps psme2, anticorps PSME2, anticorps Psme2

Sujet: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Alias Symbols: PA28B, PA28beta, REGbeta
Protein Interaction Partner: NAA10, PSMD14, SHFM1, UBC, PSME2, PSME1, PARK2, BAG3, NHLH1, MYOD1, EPHA2, CFTR, DDTL, TNN, CAP1, PTMA, PSMD7, PSMD2, PSMD1, PSMC5, PSMC4, PSMC2, PSMB5, PSMB3, PSMB1, PSMA6, PSMA5, PSMA3, PSMA2, PSMA1, GARS, APP, PSMC1, PSMD6, PSMB10, PSMB9, PSMB8, PSMB7,
Protein Size: 239

Poids moléculaire: 27 kDa

ID gène: 5721

NCBI Accession: NM_002818, NP_002809

UniProt: Q9UL46

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA