PCSK1N anticorps (N-Term)

N° du produit ABIN2787977

Détail du produit anti-PCSK1N anticorps

Antigène: PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK1N est non-conjugé

Application: Western Blotting (WB)

Séquence: STPLRLRRAV PRGEAAGAVQ ELARALAHLL EAERQERARA EAQEAEDQQA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Pcsk1n. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Pcsk1n

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 260 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PCSK1N

Antigène: PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))

Autre désignation: Pcsk1n (PCSK1N Produits)

Synonymes: anticorps PROSAAS, anticorps SAAS, anticorps Saas, anticorps AI848336, anticorps KEP, anticorps PEN, anticorps PEN19, anticorps PEN20, anticorps Pan3, anticorps SAASCT, anticorps bLEN, anticorps lLEN, anticorps proSAAS, anticorps proprotein convertase subtilisin/kexin type 1 inhibitor, anticorps PCSK1N, anticorps Pcsk1n

Sujet: Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alias Symbols: Saas
Protein Interaction Partner: STXBP5L,
Protein Size: 260

Poids moléculaire: 28 kDa

ID gène: 246333

NCBI Accession: NM_019279, NP_062152

UniProt: Q9QXU9