FGFR2 anticorps (Middle Region)
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- Antigène Voir toutes FGFR2 Anticorps
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Mouton
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FGFR2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 91%
- Attributs du produit
- This is a rabbit polyclonal antibody against FGFR2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human FGFR2
- Top Product
- Discover our top product FGFR2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 705 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
- Autre désignation
- FGFR2 (FGFR2 Produits)
- Synonymes
- anticorps FGFR2, anticorps FGFR2IIIb, anticorps bek, anticorps bfr-1, anticorps cd332, anticorps cek3, anticorps cfd1, anticorps ect1, anticorps fgfr-2, anticorps jws, anticorps k-sam, anticorps kgfr, anticorps tk14, anticorps tk25, anticorps xfgfr2, anticorps DKFZp469H1521, anticorps BBDS, anticorps BEK, anticorps BFR-1, anticorps CD332, anticorps CEK3, anticorps CFD1, anticorps ECT1, anticorps JWS, anticorps K-SAM, anticorps KGFR, anticorps TK14, anticorps TK25, anticorps AU043015, anticorps AW556123, anticorps Bek, anticorps Fgfr-2, anticorps Fgfr-7, anticorps Fgfr7, anticorps KGFRTr, anticorps svs, anticorps FGF-R, anticorps fgfr72IIIb, anticorps FGFR, anticorps fc56c05, anticorps wu:fc56c05, anticorps fibroblast growth factor receptor 2, anticorps fibroblast growth factor receptor 2 L homeolog, anticorps FGFR2, anticorps LOC100084641, anticorps fgfr2, anticorps Fgfr2, anticorps fgfr2.L
- Sujet
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The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25
Protein Interaction Partner: PPM1A, APP, HGS, UBC, LYN, FYN, CBL, NEDD4, FRS2, STAT5B, STAT5A, PGR, STAT3, ITGA5, PAK4, FGF23, FGF18, FGF17, EPHA4, FGF10, PTK2B, FGF9, FGF8, PLCG1, FGF5, FGF4, FGF3, FGF7, FGF6, FGF1, CACNA1D, PIK3R1, FGFR2,
Protein Size: 705 - Poids moléculaire
- 78 kDa
- ID gène
- 2263
- NCBI Accession
- NM_022970, NP_075259
- UniProt
- P21802
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
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