GCK anticorps (N-Term)
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- Antigène Voir toutes GCK Anticorps
- GCK (Glucokinase (Hexokinase 4) (GCK))
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Épitope
- N-Term
- Reactivité
- Humain, Souris, Rat, Mouton, Boeuf (Vache), Lapin, Cobaye, Cheval, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GCK est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against GCK. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product GCK Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 464 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." dans: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
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Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." dans: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
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- Antigène
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Autre désignation
- GCK (GCK Produits)
- Synonymes
- anticorps FGQTL3, anticorps GK, anticorps GLK, anticorps HHF3, anticorps HK4, anticorps HKIV, anticorps HXKP, anticorps LGLK, anticorps MODY2, anticorps Gk, anticorps Gls006, anticorps GCK, anticorps BA4487, anticorps glk, anticorps hk4, anticorps hhf3, anticorps hkiv, anticorps hxkp, anticorps gck-A, anticorps mody2, anticorps glucokinase, anticorps GLUKA, anticorps RNGK2, anticorps glucokinase, anticorps glucokinase (hexokinase 4) L homeolog, anticorps glucokinase (hexokinase 4), anticorps GCK, anticorps Gck, anticorps glcK, anticorps Bphyt_1025, anticorps Halhy_6548, anticorps gk, anticorps gck.L, anticorps gck
- Sujet
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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Alias Symbols: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK
Protein Interaction Partner: PCNA, GCKR, INS, PFKFB2, MIG1,
Protein Size: 464 - Poids moléculaire
- 51 kDa
- ID gène
- 2645
- NCBI Accession
- NM_033508, NP_277043
- Pathways
- Signalisation MAPK, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
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