GCK anticorps (N-Term)

N° du produit ABIN786429

Cité dans 1 publication. Cet anticorps anti-GCK Polyclonal Lapin (ABIN786429) détecte spécifiquement GCK dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Cobaye, Lapin, Mouton, Chien et Cheval.

Aperçu rapide pour GCK anticorps (N-Term) (ABIN786429)

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Cobaye, Lapin, Mouton, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GCK est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GCK anticorps

Épitope: N-Term

Fonction: GCK Antibody - N-terminal region

Séquence: RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GCK. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61473-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-GCK (ABIN786429)

Tian, Liu, Wang, Dong, Su, Ma, Zhang: "Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." dans: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).

Détails sur GCK

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Autre désignation: GCK

Sujet:

Background Information: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Gene Name: Glucokinase (hexokinase 4)

Alternative Symbols: GK, GLK, HK4, HHF3, HKIV, HXKP, LGLK, MODY2, PNDM1, FGQTL3

Protein Name: Glucokinase

Poids moléculaire: 51kDa

ID gène: 2645

NCBI Accession: NP_277043

UniProt: P35557

Pathways: Signalisation MAPK, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process