WISP1 anticorps (Middle Region)

N° du produit ABIN2789653

Cet anticorps Lapin Polyclonal détecte spécifiquement WISP1 dans WB. Il présente une réactivité envers Humain, Porc et Boeuf (Vache).

Aperçu rapide pour WISP1 anticorps (Middle Region) (ABIN2789653)

Antigène: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Reactivité: Humain, Porc, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WISP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-WISP1 anticorps

Épitope: Middle Region

Séquence: VRPPRLWCPH PRRVSIPGHC CEQWVCEDDA KRPRKTAPRD TGAFDAVGEV

Homologie: Cow: 92%, Human: 100%, Pig: 85%

Attributs du produit: This is a rabbit polyclonal antibody against WISP1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 367 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WISP1

Antigène: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Autre désignation: WISP1

Sujet: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
Alias Symbols: CCN4, WISP1c, WISP1i, WISP1tc
Protein Interaction Partner: BGN, DCN, UGGT1,
Protein Size: 367

Poids moléculaire: 38 kDa

ID gène: 8840

NCBI Accession: NM_003882, NP_003873

UniProt: O95388

Pathways: Signalisation WNT, Growth Factor Binding