Bcl-2 anticorps (N-Term)

N° du produit ABIN2792106

Cet anticorps anti-Bcl-2 Polyclonal Lapin (ABIN2792106) détecte spécifiquement Bcl-2 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Bcl-2 anticorps (N-Term) (ABIN2792106)

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Bcl-2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Bcl-2 anticorps

Épitope: N-Term

Séquence: GHTPHPAASR DPVARTSPLQ TPAAPGAAAG PALSPVPPVV HLTLRQAGDD

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BCL2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 239 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Bcl-2

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: BCL2

Sujet: The BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.
Alias Symbols: Bcl-2, PPP1R50
Protein Interaction Partner: KEAP1, SQSTM1, BECN1, UBC, TP53BP2, BID, BCL2L1, BCL2, BAX, BAD, ATP2A3, NR4A1, KRAS, PPID, MDM4, BNIP3, BFAR, CDK1, BAG3, RAF1, IKBKG, TP53, PPP3CC, FKBP8, MAPK8, IKBKB, HSP90AA1, HIF1A, CRYAB, CHUK, PML, BRCA1, AMBRA1, ATG12, BIK, CISD2, MEX3D, PPP1CC,
Protein Size: 239

Poids moléculaire: 26 kDa

ID gène: 596

NCBI Accession: NM_000633, NP_000624

UniProt: P10415

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling