BAX anticorps (N-Term)

N° du produit ABIN2792125

Cité dans 2 publications. Cet anticorps anti-BAX Polyclonal Lapin (ABIN2792125) détecte spécifiquement BAX dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Porc, Boeuf (Vache) et Chien.

Aperçu rapide pour BAX anticorps (N-Term) (ABIN2792125)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain, Porc, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-BAX anticorps

Épitope: N-Term

Fonction: BAX Antibody - N-terminal region

Séquence: MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Pig: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BAX. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BAX

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BAX (ABIN2792125)

De Martino, Marfé, Longo, Fiorito, Montagnaro, Iovane, Decaro, Pagnini: "Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis." dans: Veterinary microbiology, Vol. 141, Issue 1-2, pp. 36-45, (2010) (PubMed).

Honda, Abe, Hiroki, Honda, Iwanuma, Yanagisawa, Ide: "Activation of caspase 3, 9, 12, and Bax in masseter muscle of mdx mice during necrosis." dans: Journal of muscle research and cell motility, Vol. 28, Issue 4-5, pp. 243-7, (2007) (PubMed).

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: BAX

Sujet:

Background Information: BAX encodes a protein that belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. BAX expression is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

Gene Name: BCL2-associated X protein

Alternative Symbols: BCL2L4

Protein Name: Apoptosis regulator BAX

Poids moléculaire: 21kDa

ID gène: 581

NCBI Accession: NP_620116

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response