MDM4-binding Protein anticorps (N-Term)

N° du produit ABIN2792185

Cité dans 1 publication. Cet anticorps anti-MDM4-binding Protein Polyclonal Lapin (ABIN2792185) détecte spécifiquement MDM4-binding Protein dans WB. L’anticorps est réactif avec des échantillons de Humain, Boeuf (Vache), Porc, Lapin, Chien et Cheval.

Aperçu rapide pour MDM4-binding Protein anticorps (N-Term) (ABIN2792185)

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivité: Humain, Boeuf (Vache), Porc, Lapin, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM4-binding Protein est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MDM4-binding Protein anticorps

Épitope: N-Term

Fonction: MDM4 Antibody - N-terminal region

Séquence: IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA

Homologie: Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%

Attributs du produit: This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MDM4-binding Protein (ABIN2792185)

Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt, Kleeff, Ehemann, Eils, Lichter, Schirmacher, Radlwimmer: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." dans: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).

Détails sur MDM4-binding Protein

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Autre désignation: MDM4

Sujet:

Background Information: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Mdm4 p53 binding protein homolog (mouse)

Alternative Symbols: HDMX, MDMX, MRP1, BMFS6

Protein Name: Protein Mdm4

Poids moléculaire: 55kDa

ID gène: 4194

NCBI Accession: NP_002384

UniProt: O15151

Pathways: Cycle Cellulaire