MDM4-binding Protein anticorps (N-Term)

N° du produit ABIN2792185

Détail du produit anti-MDM4-binding Protein anticorps

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Épitope: N-Term

Reactivité: Humain, Boeuf (Vache), Lapin, Porc, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM4-binding Protein est non-conjugé

Application: Western Blotting (WB)

Séquence: IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA

Homologie: Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%

Attributs du produit: This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 490 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MDM4-binding Protein (ABIN2792185)

Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt, Kleeff, Ehemann, Eils, Lichter, Schirmacher, Radlwimmer: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." dans: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).

Détails sur MDM4-binding Protein

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Autre désignation: MDM4 (MDM4 Produits)

Synonymes: anticorps mdmx, anticorps HDMX, anticorps MDMX, anticorps MRP1, anticorps wu:fa09h09, anticorps wu:fi33d10, anticorps 4933417N07Rik, anticorps AA414968, anticorps AL023055, anticorps AU018793, anticorps AU021806, anticorps C85810, anticorps Mdmx, anticorps MDM4, p53 regulator S homeolog, anticorps MDM4, p53 regulator, anticorps transformed mouse 3T3 cell double minute 4, anticorps mdm4.S, anticorps MDM4, anticorps Mdm4, anticorps mdm4

Sujet: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX
Protein Interaction Partner: RNF115, CAPN7, CD160, MDM2, TP53, UBC, MDM4, USP2, YWHAG, UBE2D2, PRKAA1, BCL2, RPS20, RPS15, RPL37, YWHAQ, HSP90AA1, CSNK1A1, PPP1CC, PPP1CB, PPP1CA, RB1, APP, UBE2D3, UBE2D1, MNAT1, ABL1, LRSAM1, TRIM55, TRIM46, MKRN3, YWHAZ, YWHAE, YWHAB, CDKN1A, RFWD2
Protein Size: 490

Poids moléculaire: 55 kDa

ID gène: 4194

NCBI Accession: NM_002393, NP_002384

UniProt: O15151

Pathways: Cycle Cellulaire