CTNNB1 anticorps (C-Term)

N° du produit ABIN2792527

Cet anticorps Lapin Polyclonal détecte spécifiquement CTNNB1 dans WB et ChIP. Il présente une réactivité envers Humain, Souris, Chien, Poisson zèbre (Danio rerio), Cheval, Lapin et Cobaye et a été mentionné dans 1 publication.

Aperçu rapide pour CTNNB1 anticorps (C-Term) (ABIN2792527)

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Reactivité: Humain, Souris, Chien, Poisson zèbre (Danio rerio), Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTNNB1 est non-conjugé

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Détail du produit anti-CTNNB1 anticorps

Épitope: C-Term

Séquence: RTEPMAWNET ADLGLDIGAQ GEPLGYRQDD PSYRSFHSGG YGQDALGMDP

Réactivité croisée: Boeuf (Vache), Chien, Poulet, Humain, Souris, Porc, Rat (Rattus)

Homologie: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CTNNB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of human CTNNB1

Information d'application

Indications d'application: WB Suggested Anti-CTNNB1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 781 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CTNNB1 (ABIN2792527)

Li, Yang, Tang, Zhang, Feng, Cui: "Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage." dans: Journal of materials science. Materials in medicine, Vol. 26, Issue 8, pp. 227, (2015) (PubMed).

Détails sur CTNNB1

Antigène: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Autre désignation: CTNNB1 / Beta Catenin

Sujet: Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 DA216720.1 1-54 55-2626 X87838.1 1-2572 2627-3720 AC104307.2 83770-84863
Alias Symbols: CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Protein Interaction Partner: PPARD, PLA2G4A, FBXO45, BTRC, SUMO1, UBC, HUWE1, CDH5, CDH2, TCF4, TBL1X, SOX1, SKP1, RNF220, CACYBP, FBXW11, SUMO2, SIAH1, Apc2, COPS5, RNF14, CDH1, SP1, KCTD1, MDM2, UBE2B, GSK3B, NEK2, RBX1, PTGS2, STRN3, LATS2, APC, ELAVL1, AMOT, ABL1, AXIN1, CBL, LEF
Protein Size: 781

Poids moléculaire: 85 kDa

ID gène: 1499

NCBI Accession: NM_001904, NP_001895

UniProt: P35222

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2