VAV1 anticorps (Middle Region)

N° du produit ABIN2792554

Cet anticorps anti-VAV1 Polyclonal Lapin (ABIN2792554) détecte spécifiquement VAV1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Chien, Cheval, Boeuf (Vache), Porc et Lapin.

Aperçu rapide pour VAV1 anticorps (Middle Region) (ABIN2792554)

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Reactivité: Humain, Rat, Souris, Chien, Cheval, Boeuf (Vache), Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAV1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-VAV1 anticorps

Épitope: Middle Region

Fonction: VAV1 Antibody - middle region

Séquence: RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Rat (Rattus)

Homologie: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human VAV1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur VAV1

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Autre désignation: VAV1

Sujet:

Background Information: This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Vav 1 guanine nucleotide exchange factor

Alternative Symbols: VAV

Protein Name: Proto-oncogene vav

Poids moléculaire: 98kDa

ID gène: 7409

NCBI Accession: NP_005419

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling