VAV1 anticorps (Middle Region)

N° du produit ABIN2792554

Détail du produit anti-VAV1 anticorps

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Chien, Cheval, Porc, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAV1 est non-conjugé

Application: Western Blotting (WB)

Séquence: RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Rat (Rattus)

Homologie: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human VAV1

Information d'application

Indications d'application: WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 845 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur VAV1

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Autre désignation: VAV1 (VAV1 Produits)

Synonymes: anticorps VAV, anticorps Vav, anticorps vav-T, anticorps vav guanine nucleotide exchange factor 1, anticorps vav 1 oncogene, anticorps vav guanine nucleotide exchange factor 1 L homeolog, anticorps VAV1, anticorps Vav1, anticorps vav1.L

Sujet: This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: VAV
Protein Interaction Partner: UBC, CD28, ERBB3, ERBB2, EGFR, PTPN22, SPI1, PLCG1, Mbp, CD5, PDGFRB, NOTCH1, FGFR1, DOK1, TUBB, SH3BP2, CBLB, CBL, FYN, SYK, LCP2, CD19, SOCS1, KHDRBS1, LMNA, TUBA1A, PHAX, ZAP70, ZNF655, DOCK2, XRCC5, PAG1, RACGAP1, MERTK, BLNK, NEK3, AOC3, ARHGDIB, DNM
Protein Size: 845

Poids moléculaire: 98 kDa

ID gène: 7409

NCBI Accession: NM_005428, NP_005419

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling