Neuregulin 1 anticorps (Center)

N° du produit ABIN2794834

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuregulin 1 dans WB, IHC et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour Neuregulin 1 anticorps (Center) (ABIN2794834)

Antigène: Neuregulin 1 (NRG1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-Neuregulin 1 anticorps

Épitope: AA 198-229, Center

Fonction: Rabbit Anti-Human NRG1 (Center) Antibody

Immunogène: This NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot, Flow Cytometry, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, FC: 1:10-50, IHC: 1:50-100Western blot analysis of anti-NRG1 Antibody (Center) . FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. BC = breast carcinoma, HC = hepatocarcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.790 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur Neuregulin 1

Antigène: Neuregulin 1 (NRG1)

Autre désignation: NRG1

Sujet:

Target Description: Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Gene Symbol: NRG1

Poids moléculaire: 70392 Da

ID gène: 3084

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation