EPH Receptor A2 anticorps (AA 901-976) (AbBy Fluor® 594)

N° du produit ABIN2812844

Cet anticorps anti-EPH Receptor A2 est un anticorps Lapin Polyclonal détectant EPH Receptor A2 dans WB et IF (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor A2 anticorps (AA 901-976) (AbBy Fluor® 594) (ABIN2812844)

Antigène: EPH Receptor A2 (EPHA2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A2 est conjugé à/à la AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-EPH Receptor A2 anticorps (AbBy Fluor® 594)

Épitope: AA 901-976

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Monkey

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EphA2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur EPH Receptor A2

Antigène: EPH Receptor A2 (EPHA2)

Autre désignation: EphA2

Sujet:

Synonyms: ECK, CTPA, ARCC2, CTPP1, CTRCT6, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2

Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

ID gène: 1969

UniProt: P29317

Pathways: Signalisation RTK