Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) anticorps (Alexa Fluor 594)

N° du produit ABIN2814137

Détail du produit

Antigène: Coagulation Factor VIII-Associated 1 (F8A1)

Épitope: AA 2-80

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Alexa Fluor 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HAP40

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Coagulation Factor VIII-Associated 1 (F8A1)

Autre désignation: HAP40/F8a (F8A1 Produits)

Synonymes: anticorps DXS522E, anticorps F8A, anticorps HAP40, anticorps F8a, anticorps Hap40, anticorps RGD1566014, anticorps f8a, anticorps f8a1, anticorps hap40, anticorps dxs522e, anticorps MGC147036, anticorps coagulation factor VIII associated 1, anticorps coagulation factor VIII-associated 1, anticorps coagulation factor VIII, anticorps F8A1, anticorps F8a1, anticorps f8a1

Sujet:

Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.