GJA8 anticorps (N-Term)

N° du produit ABIN1882072

Détail du produit anti-GJA8 anticorps

Antigène: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Épitope: AA 99-130, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GJA8 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)

Immunogène: This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50.

Clone: RB1381

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.79 mg/mL

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Références pour anticorps anti-GJA8 (ABIN1882072)

Ponsaerts, De Vuyst, Retamal, Dhondt, Vermeire, Wang, De Smedt, Zimmermann, Himpens, Vereecke, Leybaert, Bultynck: "Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 11, pp. 4378-95, (2010) (PubMed).

Shiels, Mackay, Ionides, Berry, Moore, Bhattacharya: "A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q." dans: American journal of human genetics, Vol. 62, Issue 3, pp. 526-32, (1998) (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." dans: Current eye research, Vol. 14, Issue 10, pp. 979-81, (1996) (PubMed).

Church, Wang, Steele: "The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping." dans: Current eye research, Vol. 14, Issue 3, pp. 215-21, (1995) (PubMed).

Détails sur GJA8

Antigène: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Autre désignation: Connexin 50 (GJA8 Produits)

Synonymes: anticorps Aey5, anticorps Cnx50, anticorps Cx50, anticorps Lop10, anticorps CAE, anticorps CAE1, anticorps CTRCT1, anticorps CX50, anticorps CZP1, anticorps MP70, anticorps Cx45.6, anticorps gap junction protein, alpha 8, anticorps gap junction protein alpha 8, anticorps Gja8, anticorps GJA8

Sujet: GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

Synonyms: GJA8, Gap junction alpha-8 protein, Connexin-50, Lens fiber protein MP70

NCBI Accession: NP_005258

UniProt: P48165