ACTN1 anticorps

N° du produit ABIN2855589

Détail du produit anti-ACTN1 anticorps

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACTN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Whole Mount) (IHC (wm))

Réactivité croisée: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Attributs du produit: Rabbit Polyclonal antibody to alpha Actinin 1 (actinin, alpha 1)
alpha Actinin 1 antibody [N2N3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human alpha Actinin 1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: NIH-3T3 , 293T , A431 , HeLa , HepG2 , PC-12 , Rat2 , rat brain

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.09 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur ACTN1

Antigène: ACTN1 (Actinin, alpha 1 (ACTN1))

Autre désignation: actinin alpha 1 (ACTN1 Produits)

Synonymes: anticorps ACTN1, anticorps actinin, anticorps BDPLT15, anticorps 3110023F10Rik, anticorps Actn1a, anticorps actinin alpha 1, anticorps actinin, alpha 1, anticorps actinin alpha 1 L homeolog, anticorps ACTN1, anticorps actn1, anticorps Actn1, anticorps actn1.L

Sujet: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cytoplasm , cytoskeleton , myofibril , sarcomere , Z-disk

Poids moléculaire: 103 kDa

ID gène: 87

UniProt: P12814

Pathways: Cell-Cell Junction Organization