CD11c anticorps (FITC)

N° du produit ABIN302018

Il existe 5+ publications pour ce produit. L’anticorps anti-CD11c Monoclonal Souris est utilisé pour la détection de CD11c dans des échantillons de Humain et Singe. Il a été validé pour FACS.

Aperçu rapide pour CD11c anticorps (FITC) (ABIN302018)

Antigène: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD11c est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: BU15

Détail du produit anti-CD11c anticorps (FITC)

Fonction: Anti-Hu CD11c FITC

Réactivité croisée (Details): Human, Monkey

Attributs du produit: The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Dendritic cells of synovial fluid

Isotype: IgG1, kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze,Protect from prolonged exposure to light

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD11c (FITC) (ABIN302018)

Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." dans: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).

Sadhu, Hendrickson, Dick, Potter, Staunton: "Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies." dans: Journal of immunoassay & immunochemistry, Vol. 29, Issue 1, pp. 42-57, (2007) (PubMed).

Myou, Zhu, Boetticher, Qin, Myo, Meliton, Lambertino, Munoz, Hamann, Leff: "Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2." dans: Immunology, Vol. 107, Issue 1, pp. 77-85, (2002) (PubMed).

Van der Vieren, Le Trong, Wood, Moore, St John, Staunton, Gallatin: "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3." dans: Immunity, Vol. 3, Issue 6, pp. 683-90, (1996) (PubMed).

Hogg, Takacs, Palmer, Selvendran, Allen: "The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules." dans: European journal of immunology, Vol. 16, Issue 3, pp. 240-8, (1986) (PubMed).

Détails sur CD11c

Antigène: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Autre désignation: CD11c

Sujet: Integrin subunit alpha X,CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.,Integrin alpha X, ITGAX, SLEB6

ID gène: 3687

UniProt: P20702

Pathways: Système du Complément, Activated T Cell Proliferation, Integrin Complex