ASK1 anticorps (AA 1175-1374)

N° du produit ABIN3020875

L’anticorps Lapin Polyclonal anti-ASK1 a été validé pour WB. Il convient pour détecter ASK1 dans des échantillons de Humain.

Aperçu rapide pour ASK1 anticorps (AA 1175-1374) (ABIN3020875)

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ASK1 anticorps

Épitope: AA 1175-1374

Séquence: RPHFSLASES DTADQEDLDV EDDHEEQPSN QTVRRPQAVI EDAVATSGVS TLSSTVSHDS QSAHRSLNVQ LGRMKIETNR LLEELVRKEK ELQALLHRAI EEKDQEIKHL KLKSQPIEIP ELPVFHLNSS GTNTEDSELT DWLRVNGADE DTISRFLAED YTLLDVLYYV TRDDLKCLRL RGGMLCTLWK AIIDFRNKQT

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1175-1374 of human MAP3K5 (NP_005914.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ASK1

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Autre désignation: MAP3K5

Sujet: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.,MAP3K5,ASK1,MAPKKK5,MEKK5,Signal Transduction,Kinase,Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Actins,Death Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Cardiovascular,Heart,Hypertrophy,MAP3K5

Poids moléculaire: 69 kDa/154 kDa

ID gène: 4217

UniProt: Q99683

Pathways: Signalisation MAPK, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response