AIF anticorps (AA 334-613)

N° du produit ABIN3023385

L’anticorps Lapin Polyclonal anti-AIF a été validé pour WB, IHC, IF et IP. Il convient pour détecter AIF dans des échantillons de Humain.

Aperçu rapide pour AIF anticorps (AA 334-613) (ABIN3023385)

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-AIF anticorps

Épitope: AA 334-613

Séquence: FPEKGNMGKI LPEYLSNWTM EKVRREGVKV MPNAIVQSVG VSSGKLLIKL KDGRKVETDH IVAAVGLEPN VELAKTGGLE IDSDFGGFRV NAELQARSNI WVAGDAACFY DIKLGRRRVE HHDHAVVSGR LAGENMTGAA KPYWHQSMFW SDLGPDVGYE AIGLVDSSLP TVGVFAKATA QDNPKSATEQ SGTGIRSESE TESEASEITI PPSTPAVPQA PVQGEDYGKG VIFYLRDKVV VGIVLWNIFN RMPIARKIIK DGEQHEDLNE VAKLFNIHED

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_004199.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AIF

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Autre désignation: AIFM1

Sujet: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.,AIF,CMT2D,CMTX4,COWCK,COXPD6,DFNX5,NADMR,NAMSD,PDCD8,AIFM1,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,AIFM1

Poids moléculaire: 26 kDa/28 kDa/35 kDa/66 kDa

ID gène: 9131

UniProt: O95831

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, L'effet Warburg