ESR2 anticorps (C-Term)

N° du produit ABIN3024803

Détail du produit anti-ESR2 anticorps

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: A C-terminus fragment of recombinant human ER-b protein was used as the immunogen for the Estrogen Receptor beta antibody.

Clone: ESR2-686

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the Estrogen Receptor beta antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Estrogen Receptor beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: Estrogen Receptor beta (ESR2 Produits)

Synonymes: anticorps ER-BETA, anticorps ESR-BETA, anticorps ESRB, anticorps ESTRB, anticorps Erb, anticorps NR3A2, anticorps ER[b]1, anticorps zfER-beta1, anticorps zfER[b]1, anticorps erb2, anticorps CERB, anticorps ERB, anticorps erb, anticorps esrb, anticorps estrb, anticorps nr3a2, anticorps ERbeta, anticorps er-beta, anticorps esr-beta, anticorps ESR2, anticorps ERBETA, anticorps er, anticorps ER-beta, anticorps ER[b], anticorps Estrb, anticorps ER[b]2, anticorps ER[b]a, anticorps zfER[b]2, anticorps zfER-beta2, anticorps Erb2, anticorps esr2, anticorps erbeta, anticorps Esr2, anticorps ERBeta2, anticorps estrogen receptor 2, anticorps estrogen receptor 2b, anticorps estrogen receptor beta 2, anticorps estrogen receptor 2 (beta), anticorps estrogen receptor 2a, anticorps estrogen receptor beta, anticorps ESR2, anticorps esr2b, anticorps erb2, anticorps esr2, anticorps Esr2, anticorps esr2a, anticorps erbeta

Sujet: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling