Insulin Receptor anticorps (Chain beta, Internal Region)

N° du produit ABIN302612

L’anticorps Lapin Polyclonal anti-Insulin Receptor a été validé pour IHC (p). Il convient pour détecter Insulin Receptor dans des échantillons de Humain.

Aperçu rapide pour Insulin Receptor anticorps (Chain beta, Internal Region) (ABIN302612)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Insulin Receptor anticorps

Épitope: Chain beta, Internal Region

Specificité: This antibody detects Insulin Receptor (INSR) at internal domain.

Purification: Immunoaffinity Chromatography

Immunogène: INSR antibody was raised against synthetic peptide from internal domain of human INSR / Insulin Receptor.

Information d'application

Indications d'application: Immunohistochemistry on paraffin section (10 μg/mL)Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undlited at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: CD220 / INSR

Sujet: INSR is an insulin receptor type protein kinase. Binding of insulin to INSR stimulates glucose uptake. Two insulin receptor mRNA transcripts resulting from alternative splicing of exon 11 in the receptor gene are expressed in a highly regulated tissue-specific fashion. Mutations in the INSR gene contribute to diseases, including of various forms of insulin resistance, insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus (NIDDM), Rabson-Mendenhall syndrome and Leprechaunism (Donohue Syndrome).Synonyms: Insulin Receptor

ID gène: 3643

NCBI Accession: NP_000199

UniProt: P06213

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity