CRLF2 anticorps (Center)

N° du produit ABIN302657

Détail du produit anti-CRLF2 anticorps

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRLF2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Cytokine Receptor-like Factor 2 (CRLF2) near the center.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide - KLH conjugated corresponding to a 19 amino acid peptide from near the center of Human CRLF2.

Information d'application

Indications d'application: ELISA. Western blot: 1 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur CRLF2

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Autre désignation: CRLF2 (CRLF2 Produits)

Synonymes: anticorps CRLF2, anticorps CRL2, anticorps CRLF2Y, anticorps TSLPR, anticorps CRLM2, anticorps Ly114, anticorps Tpte2, anticorps Tslpr, anticorps Crl2, anticorps cytokine receptor like factor 2, anticorps cytokine receptor-like factor 2, anticorps CRLF2, anticorps Crlf2

Sujet: CRFL2 is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP. The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLPR has a predicted molecular weight approximately 41 kD, and two further isoforms have been reported that are produced by alternative splicing. The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.Synonyms: Cytokine receptor-like 2, Cytokine receptor-like factor 2, IL-XR, ILXR, TSLPR, Thymic stromal lymphopoietin protein receptor

ID gène: 64109

NCBI Accession: NP_071431

UniProt: Q9HC73