IRAK4 anticorps

N° du produit ABIN302830

Détail du produit anti-IRAK4 anticorps

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: This antibody reacts to a synthetic peptide corresponding to amino acids at the carboxy terminus of IRAK-4.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide

Information d'application

Indications d'application: Western Blot: 1 - 2 μg/mL. Immunohistochemistry: 5 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.

Détails sur IRAK4

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Autre désignation: IRAK4 (IRAK4 Produits)

Synonymes: anticorps zgc:55553, anticorps IRAK4, anticorps ipd1, anticorps irak-4, anticorps ny-ran-64, anticorps ny-ren-64, anticorps ren64, anticorps irak4, anticorps IPD1, anticorps IRAK-4, anticorps NY-REN-64, anticorps REN64, anticorps 8430405M07Rik, anticorps 9330209D03Rik, anticorps interleukin 1 receptor associated kinase 4, anticorps interleukin-1 receptor-associated kinase 4, anticorps IRAK4, anticorps irak4, anticorps Irak4

Sujet: IRAK4, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK4 has auto- and cross-phosphorylation kinase activity and has been shown to phosphorylate and activate IRAK1. Additionally, IRAK4 interacts with IRAK1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK4 can activate NF-kappaB as well as mitogen-activated protein (MAP) kinase pathways. IRAK4 (-/-) mice are resistant to a lethal dose of lipopolysaccharide and are severely impaired in their responses to viral and bacterial challenges. At least two mRNA transcripts have been reported: 3.0- and 4.4-kb. IRAK4, also referrred to as NY-REN-64, was first identified as an anitgen in a screen of renal tumors.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64

ID gène: 51135

NCBI Accession: NP_001107654

UniProt: Q9NWZ3

Pathways: Signalisation NF-kappaB, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades