TACR1 anticorps (Middle Region)

N° du produit ABIN3029090

Détail du produit anti-TACR1 anticorps

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human Neurokinin 1 Receptor (DSSDRYHEQVSAKRK) was used as the immunogen for this NK1R antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the NK1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the NK1R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur TACR1

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Autre désignation: NK1R Neurokinin 1 Receptor (TACR1 Produits)

Synonymes: anticorps NK1R, anticorps NKIR, anticorps SPR, anticorps TAC1R, anticorps Nk1r, anticorps Spr, anticorps Tac1r, anticorps nk1R, anticorps Tacr1, anticorps ASPR, anticorps tachykinin receptor 1, anticorps TACR1, anticorps Tacr1

Sujet: The Tachykinin receptor 1 (TACR1), also known as Neurokinin 1 receptor (NK1R) or Substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. The protein consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins. The NK1R can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to NK1R has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. NK1R antagonists have also been studied in migraine, emesis and psychiatric disorders.

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration