BAX anticorps (AA 19-33)

N° du produit ABIN3030143

L’anticorps Lapin Polyclonal anti-BAX a été validé pour WB et FACS. Il convient pour détecter BAX dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BAX anticorps (AA 19-33) (ABIN3030143)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-BAX anticorps

Épitope: AA 19-33

Purification: Antigen affinity

Immunogène: Amino acids 19-33 (IMKTGALLLQGFIQD) were used as the immunogen for this Bax antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Bax antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Bax antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: Bax

Sujet: Bcl-2 Associated X Protein is a member of the Bcl-2 gene family. The gene encodes a 21- kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. It is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. The protein is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane (alpha) and two forms of cytosolic protein (beta and gamma). Bax and Bak are essential for regulating the number of B cells at both immature and mature developmental stages. They are critical mediators of B cell death induced by multiple stimuli.

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response