HDAC8 anticorps (N-Term)

N° du produit ABIN3031236

Détail du produit anti-HDAC8 anticorps

Antigène: HDAC8 (Histone Deacetylase 8 (HDAC8))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human HDAC8 (YIYSPEYVSMCDSLAK) was used as the immunogen for this HDAC8 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the HDAC8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the HDAC8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur HDAC8

Antigène: HDAC8 (Histone Deacetylase 8 (HDAC8))

Autre désignation: HDAC8 (HDAC8 Produits)

Synonymes: anticorps HD8, anticorps CDLS5, anticorps HDACL1, anticorps MRXS6, anticorps RPD3, anticorps WTS, anticorps 2610007D20Rik, anticorps RGD1562895, anticorps wu:fd19a02, anticorps zgc:66196, anticorps ATHDA8, anticorps HDA8, anticorps HISTONE DEACETYLASE 8, anticorps T27G7.14, anticorps T27G7_14, anticorps histone deacetylase 8, anticorps histone deacetylase 8, anticorps histone deacetylase 8 L homeolog, anticorps CC1G_05302, anticorps hdac8, anticorps HDAC8, anticorps Hdac8, anticorps hdac8.L, anticorps HDA08

Sujet: Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. HDAC8 shares 54 % sequence similarity with HDAC1 and HDAC2 and 39 % similarity with HDAC3, making it a class I HDAC. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process