HSD17B6 anticorps (C-Term)

N° du produit ABIN3031275

Détail du produit anti-HSD17B6 anticorps

Antigène: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human HSD17B6 (SLADYILTRSWPKPAQAV) was used as the immunogen for this HSD17B6 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the HSD17B6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: Store the HSD17B6 antibody at -20°C.

Détails sur HSD17B6

Antigène: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Autre désignation: HSD17B6 (HSD17B6 Produits)

Synonymes: anticorps HSE, anticorps RODH, anticorps SDR9C6, anticorps 17betaHSD9, anticorps Hsd17b9, anticorps Rdh8, anticorps hydroxysteroid 17-beta dehydrogenase 6, anticorps hydroxysteroid (17-beta) dehydrogenase 6, anticorps HSD17B6, anticorps Hsd17b6

Sujet: Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action, 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.

UniProt: O14756

Pathways: Steroid Hormone Biosynthesis