PCSK4 anticorps (N-Term)

N° du produit ABIN3032335

Détail du produit anti-PCSK4 anticorps

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Épitope: N-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK4 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of mouse Proprotein convertase 4 (DPWFSKQWYMNKEIQQD) was used as the immunogen for this Proprotein Convertase 4 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Proprotein Convertase 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Proprotein Convertase 4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PCSK4

Antigène: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Autre désignation: Proprotein Convertase 4 (PCSK4 Produits)

Synonymes: anticorps PC4, anticorps SPC5, anticorps AI647044, anticorps L21221, anticorps NEC 3, anticorps NEC3, anticorps PCSK4, anticorps pc4, anticorps spc5, anticorps MGC146505, anticorps pcsk4, anticorps proprotein convertase subtilisin/kexin type 4, anticorps proprotein convertase subtilisin/kexin type 4 L homeolog, anticorps PCSK4, anticorps Pcsk4, anticorps pcsk4, anticorps pcsk4.L

Sujet: Proprotein Convertase, Subtilisin/Kexin-Type, 4, is an enzyme that in humans is encoded by the PCSK4 gene. The gene was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 may be a cause of IUGR. PCSK4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of the protein by a PCSK4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.

UniProt: P29121