GZMB anticorps (C-Term)

N° du produit ABIN3043059

Cet anticorps anti-GZMB est un anticorps Lapin Polyclonal détectant GZMB dans WB. Adapté pour Humain.

Aperçu rapide pour GZMB anticorps (C-Term) (ABIN3043059)

Antigène: GZMB (Granzyme B (GZMB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GZMB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GZMB anticorps

Épitope: AA 168-184, C-Term

Fonction: Anti-Granzyme B/GZMB Antibody Picoband®

Séquence: QEDRKCESDL RHYYDST

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Granzyme B/GZMB Antibody (ABIN3043059). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme B.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human
1. Huang, C., Bi, E., Hu. Y., Deng, W., Tian, Z., Dong, C., Hu, Y., Sun, B.A novel NF-kappa-B binding site controls human granzyme B gene transcription.J. Immun. 176: 4173-4181, 2006. 2. Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C. F. B., Gauldie, J., Bleackley, R. C.Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Cell 103: 491-500, 2000. 3. Winrow, C. J., Pankratz, D. G., Vibat, C. R. T., Bowen, T. J., Callahan, M. A., Warren, A. J., Hilbush, B. S., Wynshaw-Boris, A., Hasel, K. W., Weaver, Z., Lockhart, D. J., Barlow, C.Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.Hum. Molec. Genet. 14: 2671-2684, 2005.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GZMB

Antigène: GZMB (Granzyme B (GZMB))

Autre désignation: GZMB

Sujet:

Synonyms: Granzyme B,3.4.21.79,C11,CTLA-1,Cathepsin G-like 1,CTSGL1,Cytotoxic T-lymphocyte proteinase 2,Lymphocyte protease,Fragmentin-2,Granzyme-2,Human lymphocyte protein,HLP,SECT,T-cell serine protease 1-3E,GZMB,CGL1, CSPB, CTLA1, GRB,

Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are though to protect their host by inducing apoptosis of cells that bear on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Sequence Similarities: Belongs to the peptidase S1 family. Granzyme subfamily.

Poids moléculaire: 55 kDa

UniProt: P10144

Pathways: Apoptose, Caspase Cascade in Apoptosis