LKB1 anticorps (AA 62-430)

N° du produit ABIN3043300

Cet anticorps Lapin Polyclonal détecte spécifiquement LKB1 dans WB. Il présente une réactivité avec des échantillons de Humain.Il a été cité dans 1 publication.

Aperçu rapide pour LKB1 anticorps (AA 62-430) (ABIN3043300)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LKB1 anticorps

Épitope: AA 62-430

Fonction: Anti-LKB1/STK11 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-LKB1/STK11 Antibody (ABIN3043300). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human LKB1 recombinant protein (Position: K62-C430). Human LKB1 shares 89% amino acid (aa) sequence identity with both mouse and rat LKB1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-LKB1 (ABIN3043300)

Tang, Li, Wang, Threadgill, Xiao, Mou, Song, Kuang, Yang, Yang, Gao, Wang, Meng: "ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma." dans: American journal of cancer research, Vol. 5, Issue 2, pp. 498-513, (2015) (PubMed).

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11

Sujet:

Synonyms: Serine/threonine-protein kinase STK11,2.7.11.1,Liver kinase B1,LKB1,hLKB1,Renal carcinoma antigen NY-REN-19,STK11,LKB1, PJS,

Tissue Specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Background: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere ion.

Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

Poids moléculaire: 60 kDa

ID gène: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg