SERPINH1 anticorps (AA 247-418)

N° du produit ABIN3043331

Détail du produit anti-SERPINH1 anticorps

Antigène: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Épitope: AA 247-418

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SERPINH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Serpin H1(SERPINH1) detection. Tested with WB, IHC-P in Human,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Serpin H1(SERPINH1) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Protein Name: Serpin H1

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Hsp47 recombinant protein (Position: D247-L418). Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp47.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Hsp47 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur SERPINH1

Antigène: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Autre désignation: SERPINH1 (SERPINH1 Produits)

Synonymes: anticorps AsTP3, anticorps CBP1, anticorps CBP2, anticorps HSP47, anticorps OI10, anticorps PPROM, anticorps RA-A47, anticorps SERPINH2, anticorps gp46, anticorps SERPINH1, anticorps DKFZp468B197, anticorps cb216, anticorps hsp, anticorps hsp47, anticorps id:ibd5060, anticorps wu:fc56b02, anticorps BERF-1, anticorps Cbp1, anticorps Cbp2, anticorps Hsp47, anticorps J6, anticorps Serpinh2, anticorps colligin, anticorps astp3, anticorps cbp1, anticorps cbp2, anticorps pig14, anticorps pprom, anticorps ra-a47, anticorps serpinh2, anticorps serpin family H member 1, anticorps serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b, anticorps serpin H1, anticorps selenoprotein K, anticorps serine (or cysteine) peptidase inhibitor, clade H, member 1, anticorps serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) L homeolog, anticorps SERPINH1, anticorps serpinh1b, anticorps LOC100009353, anticorps Selenok, anticorps Serpinh1, anticorps serpinh1.L

Classe de substances: Viral Protein

Sujet: Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen, thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.

Synonyms: 47 kDa heat shock protein antibody|47 kDa heat shock protein precursor antibody|Arsenic transactivated protein 3 antibody|Arsenic-transactivated protein 3 antibody|AsTP 3 antibody|AsTP3 antibody|CBP 1 antibody|CBP 2 antibody|CBP1 antibody|CBP2 antibody|Cell proliferation-inducing gene 14 protein antibody|Collagen binding protein 1 antibody|Collagen binding protein 2 antibody|Collagen binding protein antibody|Collagen-binding protein 2 antibody|Collagen-binding protein antibody|Colligen antibody|Colligin 1 antibody|Colligin 2 antibody|Colligin antibody|colligin-1 antibody|colligin-2 antibody|gp46 antibody|Heat shock protein 47 antibody|Heat-shock protein 47 antibody|HGNC 1547 antibody|Hsp 47 antibody|J6 antibody|OI10 antibody|PIG 14 antibody|PIG14 antibody|PPROM antibody|Proliferation inducing gene 14 antibody|Proliferation inducing gene 14 protein antibody|RA A47 antibody|RA-A47 antibody|Rheumatoid arthritis antigen A 47 antibody|rheumatoid arthritis antigen A-47 antibody|Rheumatoid arthritis related antigen RA A47 antibody|Rheumatoid arthritis-related antigen RA-A47 antibody|serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody|serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2) antibody|Serine or cysteine proteinase inhibitor clade H member 1 antibody|Serine or cysteine proteinase inhibitor clade H member 2 antibody|SERPH_HUMAN antibody|Serpin H1 antibody|Serpin peptidase inhibitor clade H member 1 antibody|serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody|Serpin peptidase inhibitor, clade H, member 1 antibody|SERPINH1 antibody|SERPINH2 antibody

ID gène: 871

UniProt: P50454