NFKBIB anticorps (AA 56-237)

N° du produit ABIN3043567

Cet anticorps Lapin Polyclonal détecte spécifiquement NFKBIB dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour NFKBIB anticorps (AA 56-237) (ABIN3043567)

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NFKBIB anticorps

Épitope: AA 56-237

Fonction: Anti-IKB beta/NFKBIB Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-IKB beta/NFKBIB Antibody Picoband® (ABIN3043567). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human IKB beta recombinant protein (Position: E56-E237). Human IKB beta shares 82% and 80% amino acid (aa) sequence identity with mouse and rat IKB beta, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Okamoto T, Ono T, Hori M, Yang J, Tetsuka T, Kawabe T et al. (November 1998). "Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization". Cytogenet Cell Genet 82 (1-2): 105-6. 2. Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., Oeckinghaus, A., Lynch, C., Hoffmann, A., Baltimore, D., Ghosh, S. I-kappa-B-beta acts to inhibit and activate gene expression during the inflammatory response. Nature 466: 1115-1119, 2010.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur NFKBIB

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Autre désignation: NFKBIB

Sujet:

Synonyms: NF-kappa-B inhibitor beta,NF-kappa-BIB,I-kappa-B-beta,IkB-B,IkB-beta,IkappaBbeta,Thyroid receptor-interacting protein 9,TR-interacting protein 9,TRIP-9,NFKBIB,IKBB, TRIP9,

Tissue Specificity: Expressed in all tissues examined.

Background: NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. This gene is mapped to 19q13.2. It has been found that in vivo, NFKBIB serves both to inhibit and to facilitate the inflammatory response. NFKBIB degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as TNF-alpha. Surprisingly, absence of NFKBIB results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.

Sequence Similarities: Belongs to the NF-kappa-B inhibitor family.

Poids moléculaire: 38 kDa

ID gène: 4793

UniProt: Q15653

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades