PKC gamma anticorps (C-Term)

N° du produit ABIN3043714

Détail du produit anti-PKC gamma anticorps

Antigène: PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))

Épitope: AA 665-685, C-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC gamma est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Protein kinase C gamma type(PRKCG) detection. Tested with WB in Human,Mouse,Rat.

Séquence: IDQADFQGFT YVNPDFVHPD A

Réactivité croisée (Details): Predicted Cross Reactivity: human, mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Protein kinase C gamma type(PRKCG) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: protein kinase C, gamma
Protein Name: Protein kinase C gamma type(PKC-gamma)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human PKC gamma(665-685aa IDQADFQGFTYVNPDFVHPDA), identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-PKC gamma (ABIN3043714)

Gan, Wang, Zhao, Wu, Yang, Peng: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." dans: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).

Zhang, Xu, Song, Yao, Ji: "Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity." dans: Journal of translational medicine, Vol. 12, pp. 236, (2015) (PubMed).

Détails sur PKC gamma

Antigène: PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))

Autre désignation: PRKCG (PRKCG Produits)

Synonymes: anticorps PRKCG, anticorps PKC-gamma, anticorps PKCC, anticorps PKCG, anticorps SCA14, anticorps PKCgamma, anticorps Pkcc, anticorps Prkcc, anticorps PKC, anticorps PKCI, anticorps Prkc, anticorps RATPKCI, anticorps protein kinase C gamma, anticorps protein kinase C, gamma, anticorps protein kinase C gamma type, anticorps PRKCG, anticorps Prkcg, anticorps LOC484316

Sujet: The gamma isotype of protein kinase C(PKC gamma) is a member of the classical PKC(cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine. Physiologically, PKC gamma is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes such as PKC alpha and PKC beta. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons, while PKC alpha and PKC beta are expressed in many tissues in addition to the brain. Within the brain, PKC gamma is the most abundant in the cerebellum, hippocampus and cerebral cortex, where the existence of neuronal plasticity has been demonstrated. PKC gamma gene is mutated in spinocerebellar ataxia type 14(SCA14). Verbeek et al.(2005) point out the specific alterations in mutant PKC gamma function that could lead to the selective neuronal degeneration of SCA14.

Synonyms: KPCG_HUMAN antibody|MGC57564 antibody|OTTHUMP00000067291 antibody|PKC-gamma antibody|PKCC antibody|PKCG antibody|PRKCG antibody|Protein kinase C gamma antibody|Protein kinase C gamma polypeptide antibody|Protein kinase C gamma type antibody|Protein kinase C, gamma antibody|SCA 14 antibody|SCA14 antibody

UniProt: P05129

Pathways: Signalisation WNT, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGF Signaling