NRP2 anticorps (N-Term)

N° du produit ABIN3044160

Détail du produit anti-NRP2 anticorps

Antigène: NRP2 (Neuropilin 2 (NRP2))

Épitope: AA 45-60, N-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NRP2 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Neuropilin-2(NRP2) detection. Tested with WB in Human,Mouse,Rat.

Séquence: YPQDYPSHQN CEWIVY

Réactivité croisée (Details): Predicted Cross Reactivity: human, mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Neuropilin-2(NRP2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: neuropilin 2
Protein Name: Neuropilin-2

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human NRP2(45-60aa YPQDYPSHQNCEWIVY), identical to the related mouse sequence and different from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NRP2

Antigène: NRP2 (Neuropilin 2 (NRP2))

Autre désignation: NRP2 (NRP2 Produits)

Synonymes: anticorps NP2, anticorps NPN2, anticorps PRO2714, anticorps VEGF165R2, anticorps 1110048P06Rik, anticorps Np-2, anticorps Np2, anticorps Npn-2, anticorps Npn2, anticorps neuropilin-2, anticorps neuropilin 2, anticorps NRP2, anticorps Nrp2

Sujet: NRP2(Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped on 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3(PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in Npn2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

Synonyms: MGC126574 antibody|Neuropilin 2 antibody|Neuropilin-2 antibody|Neuropilin2 antibody|NP 2 antibody|NP2 antibody|NPN 2 antibody|NPN2 antibody|NRP 2 antibody|Nrp2 antibody|NRP2_HUMAN antibody|PRO2714 antibody|Receptor for VEGF165 and semaphorins class3 antibody|Vascular endothelial cell growth factor 165 receptor 2 antibody|Vascular endothelial growth factor 165 receptor 2 antibody|VEGF1265R2 antibody|VEGF165R2 antibody

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals