FGF8 anticorps (C-Term)

N° du produit ABIN3044346

Détail du produit anti-FGF8 anticorps

Antigène: FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

Épitope: AA 163-185, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGF8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Fibroblast growth factor 8(FGF8) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: FMKRLPRGHH TTEQSLRFEF LNY

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Fibroblast growth factor 8(FGF8) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: fibroblast growth factor 8(androgen-induced)
Protein Name: Fibroblast growth factor 8(FGF-8)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human FGF8(163-185aa FMKRLPRGHHTTEQSLRFEFLNY), identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur FGF8

Antigène: FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

Autre désignation: FGF8 (FGF8 Produits)

Synonymes: anticorps Aigf, anticorps Fgf-8, anticorps AIGF, anticorps FGF-8, anticorps HBGF-8, anticorps HH6, anticorps KAL6, anticorps fibroblast growth factor 8, anticorps Fgf8, anticorps FGF8

Sujet: Fibroblast growth factor 8(androgen-induced), also known as FGF8 or AIGF, is a human gene which maps to 10q24. The protein encoded by this gene are secreted proteins that interact with FGF tyrosine kinase receptors to mediate growth and development. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The temporal and spatial patterns of this gene expression suggest that FGF8 is involved in gastrulation, regionalization of the brain, and organogenesis of the limb and face as an embryonic epithelial factor. The adult expression of FGF8 is restricted to gonads, including testes and ovaries. FGF8 stimulated growth of human prostate carcinoma cells and mouse fibroblasts and mammary carcinoma cells in a dose-dependent manner. It also may play an important role in growth and patterning of limbs, face, and central nervous system. FGF8 is expressed in increased levels in breast cancer and in lactating human breast, it was also detected in human milk. A survey of other normal tissues showed that FGF8 is expressed in the proliferative cells of the skin and epithelial cells in colon, ovary, fallopian tube, and uterus.

Synonyms: AIGF antibody|Androgen induced growth factor antibody|Androgen-induced growth factor antibody|FGF 8 antibody|FGF-8 antibody|FGF8 antibody|FGF8_HUMAN antibody|Fibroblast growth factor 8(androgen induced) antibody|Fibroblast growth factor 8 antibody|Fibroblast growth factor 8 precursor antibody|HBGF 8 antibody|HBGF-8 antibody|HBGF8 antibody|Heparin-binding growth factor 8 antibody

UniProt: P55075

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis