PPP1CA anticorps

N° du produit ABIN306640

Cet anticorps Souris Monoclonal détecte spécifiquement PPP1CA dans WB, IP, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour PPP1CA anticorps (ABIN306640)

Antigène: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPP1CA est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PPP1CA anticorps

Specificité: P16 INK4a

Réactivité croisée: Humain

Réactivité croisée (Details): Human, other species not tested

Attributs du produit: pp1a, rabbit anti protein phosphatase 1 alpha,The antibody is suitable to detect p16 in different tissues. Staining results may be cytoplasmatic or nuclear. Nuclear staining should be more specific. Human p16 INK4a (syn. CDKN2, MTS-1) protein is an inhibitor of Cyclin-Dependent-Kinases 4 and 6 (cdk4/cdk6). CDK4 is an important enzyme for the progression of the cell cycle during the G1-Phase. By it's inhibitory action p16 is an important regulator in the cell cycle. The gen encoding for p16 is deleted in many tumour cell lines. In adenocarcinoma of the cervix uteri usually p16 levels are increased. Endocervical p16-overexpression is mostly associated with "high risk" HPV-Typing. In other tumour types as squamous epithelial carcinoma in cervix uteri and head and neck carcinoma p16 expression usually is reduced.

Purification: Protein A affinity purification.

Immunogène: Recombinant human p16 INK4a molecule,Monoclonal antibody DCS-50 is produced after immunisation of Balb/c mice with the full length recombinant p16 INK4a protein of human origin.

Isotype: IgG

Information d'application

Indications d'application: Pre-treatment with Unmasking Fluid C (Citrate Buffer) or Unmasking Fluid G at 96-100 degree of Celsius is recommended for paraffin sections.,IHC (C,P), IP,60 min at RT,1:10

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: Protein A affinity purified antibody lyophilized from PBS pH 7.4 with BSA and Na-Azide 0.09 % .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur PPP1CA

Antigène: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Autre désignation: Protein Phosphatase 1 alpha

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism