PPP1CA anticorps (Catalytic Subunit)

N° du produit ABIN7169304

Détail du produit anti-PPP1CA anticorps

Antigène: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Épitope: AA 192-330, Catalytic Subunit

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1CA est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit protein (192-330AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PPP1CA

Antigène: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Autre désignation: PPP1CA (PPP1CA Produits)

Synonymes: anticorps PP-1A, anticorps PP1A, anticorps PP1alpha, anticorps PPP1A, anticorps Ppp1c, anticorps dism2, anticorps ppp1a, anticorps wu:fc04c08, anticorps wu:fc09b07, anticorps wu:fc30g11, anticorps wu:fe05h08, anticorps zgc:85729, anticorps Ppp1ca, anticorps fb18b03, anticorps fd20h04, anticorps wu:fb18b03, anticorps wu:fd20h04, anticorps wu:fl22a03, anticorps zgc:55744, anticorps zgc:76940, anticorps protein phosphatase 1 catalytic subunit alpha, anticorps protein phosphatase 1, catalytic subunit, alpha isoform, anticorps protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog, anticorps protein phosphatase 1, catalytic subunit, alpha isozyme, anticorps protein phosphatase 1, catalytic subunit, alpha isozyme a, anticorps protein phosphatase 1, catalytic subunit, alpha isozyme b, anticorps PPP1CA, anticorps Ppp1ca, anticorps ppp1ca.L, anticorps ppp1ca, anticorps ppp1caa, anticorps ppp1cab

Sujet:

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the \'Ser-418\' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Aliases: Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit antibody, Catalytic subunit antibody, EC 3.1.3.16 antibody, MGC15877 antibody, MGC1674 antibody, PP 1A antibody, PP-1A antibody, PP1A antibody, PP1A_HUMAN antibody, PP1alpha antibody, PP2C ALPHA antibody, PP2CA antibody, Ppp1ca antibody, Protein Phosphatase 2C Alpha Isoform antibody, Serine threonine protein phosphatase PP1 alpha catalytic subunit antibody, Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1 antibody, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody

UniProt: P62136

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism