Caspase 8 anticorps

N° du produit ABIN306795

Cet anticorps anti-Caspase 8 Monoclonal Souris (Clone FLICE 1 1-37) (ABIN306795) détecte spécifiquement Caspase 8 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Caspase 8 anticorps (ABIN306795)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB)

Clone: FLICE 1 1-37

Détail du produit anti-Caspase 8 anticorps

Fonction: Mouse anti Human Caspase-8

Réactivité croisée: Humain

Attributs du produit: Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains which are removed to activate the enzyme along with cleavage into the two subunits. These subunits then for the active protease which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.

Purification: Protein A/G Chromatography

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human capase-8 protein and mouse myeloma cells.

Isotype: IgG

Information d'application

Indications d'application: Detects proenzyme form of human Caspase-8 by Western blot analysis as well as one of the cleavage products. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: Caspase-8

Sujet: Cysteine-requiring Aspartate Protease-8, Apoptotic protease Mch-5, ICE-like apoptotic protease 5, FADD-like ICE

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades