BAX anticorps

N° du produit ABIN306834

Cet anticorps anti-BAX est un anticorps Mouton Polyclonal détectant BAX dans WB et IP. Adapté pour Souris.

Aperçu rapide pour BAX anticorps (ABIN306834)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Souris

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-BAX anticorps

Réactivité croisée: Souris

Attributs du produit: Apoptosis regulator Bax cytoplasmic isoform beta , BaxB, BAX, BCL2 associated X protein, Apoptosis regulator BAX, BCL2 associated X protein isoform beta, Bax beta, Bax B,Bax is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax protein before a stop codon is encountered during translation. The Bax protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax mRNA was very abundant in brain and duodenum with almost no Bax mRNA detected in these tissues (Oltvai et al., 1993).

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide corresponding to amino acids 172 to 199 of theBax protein

Isotype: IgG

Information d'application

Indications d'application: Antibody detects Bax? protein by immunoprecipitation only. Will not detect denatured protein by Western blot. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: Bax-beta

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response