SPHK1 anticorps

N° du produit ABIN306932

L’anticorps anti-SPHK1 Polyclonal Lapin est utilisé pour la détection de SPHK1 dans des échantillons de Humain, Souris, Rat et Boeuf (Vache). Il a été validé pour WB et ELISA.

Aperçu rapide pour SPHK1 anticorps (ABIN306932)

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SPHK1 anticorps

Fonction: Rabbit anti Human Sphingosine Kinase 1

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat

Attributs du produit: Sphingosine Kinase 1 (Sphk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

Purification: Antigen Immunoaffiinity Purification

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (1:400 dilution) and ELISA. Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur SPHK1

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Autre désignation: Sphingosine Kinase 1

Sujet: EC 2.7.1, SK 1, SPK 1, SPHK1, Gene name: SPHK1 or SPHK or SP

UniProt: Q9NYA1

Pathways: VEGF Signaling