NOTUM anticorps

N° du produit ABIN307025

Détail du produit anti-NOTUM anticorps

Antigène: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTUM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Attributs du produit: Pectinacetylesterase homolog, Wingful (Wf),Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the / -hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

Purification: Ammonium Sulfate Precipitation

Immunogène: Rabbits were immunized with recombinant full-length notum protein from mouse.

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (5-10 μg/mL) and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur NOTUM

Antigène: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Autre désignation: Notum (NOTUM Produits)

Synonymes: anticorps 5730593N15Rik, anticorps RGD1307119, anticorps notum, palmitoleoyl-protein carboxylesterase, anticorps notum pectinacetylesterase homolog (Drosophila), anticorps NOTUM, palmitoleoyl-protein carboxylesterase, anticorps NOTUM, anticorps Notum