CYP26A1 anticorps (C-Term)

N° du produit ABIN307114

Détail du produit anti-CYP26A1 anticorps

Antigène: CYP26A1 (Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CYP26A1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Attributs du produit: CYP450 26 (EC 1.14.-.-), Retinoic acid-metabolizing cytochrome, P450 retinoic acid-inactivating 1, P450RAI, hP450RAI, Retinoic acid 4-hydroxylase,The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1, also referred to as retinoic acid-4-hydroxylase, is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptors 2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli(mcr) mutant zebrafish embryos.

Purification: Protein A/G Chromatography

Immunogène: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human CYP450 26A1 protein and mouse myeloma Ag8563 cells.

Clone: F27 P6 A1

Isotype: IgG2b

Information d'application

Indications d'application: Antibody can be used for Western blotting (1-2 μg/mL) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CYP26A1

Antigène: CYP26A1 (Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1))

Autre désignation: Cytochrome p450 26A1 (CYP26A1 Produits)

Synonymes: anticorps CP26, anticorps CYP26, anticorps P450RAI, anticorps P450RAI1, anticorps Cyp26, anticorps P450RA, anticorps RAH, anticorps RACE, anticorps XCYP26A1, anticorps cyp26, anticorps xCYP26, anticorps cp26, anticorps p450rai, anticorps p450rai1, anticorps CYP26A, anticorps cb24, anticorps id:ibd5061, anticorps wu:fb81e05, anticorps cytochrome P450 family 26 subfamily A member 1, anticorps cytochrome P450, family 26, subfamily a, polypeptide 1, anticorps cytochrome P450 family 26 subfamily A member 1 S homeolog, anticorps cytochrome P450 family 26 subfamily A member 1 L homeolog, anticorps cytochrome P450, family 26, subfamily A, polypeptide 1, anticorps CYP26A1, anticorps Cyp26a1, anticorps cyp26a1.S, anticorps cyp26a1.L, anticorps cyp26a1

Pathways: Retinoic Acid Receptor Signaling Pathway, Monocarboxylic Acid Catabolic Process