GTPBP1 anticorps

N° du produit ABIN317811

Détail du produit anti-GTPBP1 anticorps

Antigène: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GTPBP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: GBP1 antibody detects endogenous levels of GBP1 protein.(region surrounding Glu99)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GTPBP1

Antigène: GTPBP1 (GTP Binding Protein 1 (GTPBP1))

Autre désignation: GTP-Binding Protein 1 / GBP1 (GTPBP1 Produits)

Synonymes: anticorps GP-1, anticorps GP1, anticorps HSPC018, anticorps AL022987, anticorps AW045683, anticorps C85212, anticorps Gtpbp, anticorps cb858, anticorps wu:fb36e06, anticorps wu:fi39g05, anticorps zgc:66228, anticorps gtpbp1, anticorps GTP binding protein 1, anticorps GTP binding protein 1 S homeolog, anticorps GTPBP1, anticorps Gtpbp1, anticorps gtpbp1, anticorps gtpbp1.S

Sujet: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi's sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.Synonyms: Guanine nucleotide-binding protein 1, HuGBP-1, Interferon-induced guanylate-binding protein 1

Poids moléculaire: approx. 68 kDa

ID gène: 2633

NCBI Accession: NP_002044

UniProt: P32455